ZIC3 - Zinc finger protein ZIC 3 - human protein (Function)
 
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ZIC3 »  Zinc finger protein ZIC 3
 
Protein also known as:  Zinc finger protein of the cerebellum 3.
Gene name:  ZIC3
Entry whose protein(s) existence is based on evidence at protein level
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1 32 2
GENE REF ISO

Function

 show evidences
Overview 
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Determination of digestive tract left/right asymmetrydefinition[GO:0071907]  
1
  • IMPBHF-UCL
Determination of left/right asymmetry in nervous systemdefinition[GO:0035545] silver  
  • IEAOrtholog Compara
Determination of left/right symmetrydefinition[GO:0007368]  
1
  • IMPBHF-UCL
Determination of liver left/right asymmetrydefinition[GO:0071910]  
1
  • IMPBHF-UCL
Determination of pancreatic left/right asymmetrydefinition[GO:0035469]  
1
  • IMPBHF-UCL
Heart loopingdefinition[GO:0001947]  
1
  • IMPBHF-UCL
Lung developmentdefinition[GO:0030324]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZIC3
GenomeRNAi: 7547
PRO: PR:O60481