ACSL4 - Long-chain-fatty-acid--CoA ligase 4 - human protein (Function)
 
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ACSL4 »  Long-chain-fatty-acid--CoA ligase 4   [ EC 6.2.1.3 ]
 
Protein also known as:  Long-chain acyl-CoA synthetase 4 (LACS 4).
Gene name:  ACSL4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 45 2
GENE REF ISO

Function

 show evidences
Overview 
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.  
  • CuratedUniProtKB
GO molecular function 
Arachidonate-CoA ligase activitydefinition[GO:0047676]  
2
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
2
  • IDAUniProtKB
  • IDAMGI
Very long-chain fatty acid-CoA ligase activitydefinition[GO:0031957]  
1
  • IMPUniProtKB
GO biological process 
Dendritic spine developmentdefinition[GO:0060996] silver  
  • IEAOrtholog Compara
Embryonic process involved in female pregnancydefinition[GO:0060136] silver  
  • IEAOrtholog Compara
Fatty acid transportdefinition[GO:0015908] silver  
  • IEAOrtholog Compara
Isoform  Short   Lipid biosynthetic processdefinition[GO:0008610]  
1
  • IDAUniProtKB
Lipid metabolic processdefinition[GO:0006629]  
1
  • IDAUniProtKB
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
2
  • IDAGOC
Isoform  Short   Negative regulation of prostaglandin secretiondefinition[GO:0032307]  
1
  • IDAUniProtKB
Isoform  Short   Positive regulation of cell growthdefinition[GO:0030307]  
1
  • IDAUniProtKB
Response to interleukin-15definition[GO:0070672] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+2182  
Fatty acid metabolism  hsa00071+2182  
Metabolic pathways  hsa01100+2182  
Peroxisome  hsa04146+2182  
PPAR signaling pathway  hsa03320+2182  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSL4
GenomeRNAi: 2182
PRO: PR:O60488