CUBN - Cubilin - human protein (Function)
 
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Protein
Gene
References

 
CUBN »  Cubilin
 
Protein also known as:  Intrinsic factor-vitamin B12 receptor.
Gene name:  CUBN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.  
6
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Cobalamin bindingdefinition[GO:0031419]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Receptor activitydefinition[GO:0004872] silver  
1
  • InterPro 2 GO
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • UniProtKB KW
Cobalamin transportdefinition[GO:0015889]  
1
  • PINC
Lipoprotein transportdefinition[GO:0042953] silver  
1
  • Ortholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • UniProtKB
Tissue homeostasisdefinition[GO:0001894]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vitamin digestion and absorption  hsa04977+8029  
According to Reactome, this protein belongs to the following pathways:
Cobalamin (Cbl, vitamin B12) transport and metabolism  REACT_163862  
Defective AMN causes hereditary megaloblastic anemia 1  REACT_169280  
Defective CUBN causes hereditary megaloblastic anemia 1  REACT_169132  
HDL-mediated lipid transport  REACT_13621  
Vitamin D (calciferol) metabolism  REACT_13523  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Endocytosis  definition   [KW-0254]
Lipid metabolism  definition   [KW-0443]
Protein transport  definition   [KW-0653]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cubilin
GenomeRNAi: 8029
PRO: PR:O60494