ADCY9 - Adenylate cyclase type 9 - human protein (Function)
 
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ADCY9 »  Adenylate cyclase type 9   [ EC 4.6.1.1 ]
 
Protein also known as:  Adenylate cyclase type IX.
Gene name:  ADCY9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+115  
Calcium signaling pathway  hsa04020+115  
Chemokine signaling pathway  hsa04062+115  
Cholinergic synapse  hsa04725+115  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+115  
GABAergic synapse  hsa04727+115  
Gap junction  hsa04540+115  
Gastric acid secretion  hsa04971+115  
Glutamatergic synapse  hsa04724+115  
GnRH signaling pathway  hsa04912+115  
HTLV-I infection  hsa05166+115  
Melanogenesis  hsa04916+115  
Oocyte meiosis  hsa04114+115  
Pancreatic secretion  hsa04972+115  
Progesterone-mediated oocyte maturation  hsa04914+115  
Purine metabolism  hsa00230+115  
Salivary secretion  hsa04970+115  
Vascular smooth muscle contraction  hsa04270+115  
Vasopressin-regulated water reabsorption  hsa04962+115  
Vibrio cholerae infection  hsa05110+115  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY9
GenomeRNAi: 115
PRO: PR:O60503