ADCY9 - Adenylate cyclase type 9 - human protein (Function)
 
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Protein
Gene
References

 
ADCY9 »  Adenylate cyclase type 9   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 9.
Gene name:  ADCY9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed9628827, PubMed12972952, PubMed15879435, PubMed10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed9628827).  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • UniProtKB
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
GO biological process 
Adenylate cyclase-activating adrenergic receptor signaling pathwaydefinition[GO:0071880]  
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  • UniProtKB
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
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  • UniProtKB
cAMP biosynthetic processdefinition[GO:0006171]  
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  • UniProtKB
  • RefGenome
cAMP-mediated signalingdefinition[GO:0019933]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
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  • UniProtKB
It is regulated in the following manner
Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation (PubMed9628827). Activity is down-regulated by calcium/calcineurin (PubMed10987815).  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+115  
Calcium signaling pathway  hsa04020+115  
Chemokine signaling pathway  hsa04062+115  
Cholinergic synapse  hsa04725+115  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+115  
GABAergic synapse  hsa04727+115  
Gap junction  hsa04540+115  
Gastric acid secretion  hsa04971+115  
Glutamatergic synapse  hsa04724+115  
GnRH signaling pathway  hsa04912+115  
HTLV-I infection  hsa05166+115  
Melanogenesis  hsa04916+115  
Oocyte meiosis  hsa04114+115  
Pancreatic secretion  hsa04972+115  
Progesterone-mediated oocyte maturation  hsa04914+115  
Purine metabolism  hsa00230+115  
Salivary secretion  hsa04970+115  
Vascular smooth muscle contraction  hsa04270+115  
Vasopressin-regulated water reabsorption  hsa04962+115  
Vibrio cholerae infection  hsa05110+115  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY9
GenomeRNAi: 115
PRO: PR:O60503