GMDS - GDP-mannose 4,6 dehydratase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GMDS »  GDP-mannose 4,6 dehydratase   [ EC 4.2.1.47 ]
 
Protein also known as:  GDP-D-mannose dehydratase (GMD).
Gene name:  GMDS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.  
  • CuratedUniProtKB
GO molecular function 
GDP-mannose 4,6-dehydratase activitydefinition[GO:0008446]  
2
  • IGIUniProtKB
NADP+ bindingdefinition[GO:0070401]  
1
  • IDAUniProtKB
GO biological process 
'de novo' GDP-L-fucose biosynthetic processdefinition[GO:0042351]  
1
  • IDAUniProtKB
  • IEAUniPathway
GDP-mannose metabolic processdefinition[GO:0019673]  
2
  • IGIUniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.47: GDP-alpha-D-mannose GDP-4-dehydro-alpha-D-rhamnose + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
NADP.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+2762  
Fructose and mannose metabolism  hsa00051+2762  
Metabolic pathways  hsa01100+2762  
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GMDS_(gene)
GenomeRNAi: 2762
PRO: PR:O60547