TLR5 - Toll-like receptor 5 - human protein (Function)
 
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TLR5 »  Toll-like receptor 5
 
Protein also known as:  Toll/interleukin-1 receptor-like protein 3.
Gene name:  TLR5
Family name: Toll-like receptor
Entry whose protein(s) existence is based on evidence at protein level
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1 131 1
GENE REF ISO

Function

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Overview 
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  
1
  • CuratedUniProtKB
GO molecular function 
Interleukin-1 receptor bindingdefinition[GO:0005149]  
1
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Defense response to bacteriumdefinition[GO:0042742] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDABHF-UCL
Positive regulation of toll-like receptor signaling pathwaydefinition[GO:0034123]  
1
  • IDABHF-UCL
Regulation of cytokine secretiondefinition[GO:0050707] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Legionellosis  hsa05134+7100  
Pathogenic Escherichia coli infection  hsa05130+7100  
Salmonella infection  hsa05132+7100  
Toll-like receptor signaling pathway  hsa04620+7100  
According to Reactome, this protein belongs to the following pathways:
MyD88 cascade initiated on plasma membrane  REACT_27215  
Toll Like Receptor 5 (TLR5) Cascade  REACT_9061  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TLR_5
GenomeRNAi: 7100
PRO: PR:O60602
Chemistry
GuidetoPHARMACOLOGY: 1755