TLR2 - Toll-like receptor 2 - human protein (Function)
 
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Protein
Gene
References

 
TLR2 »  Toll-like receptor 2
 
Protein also known as:  Toll/interleukin-1 receptor-like protein 4; CD antigen CD282.
Gene name:  TLR2
Family name: Toll-like receptor
Entry whose protein(s) existence is based on evidence at protein level
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1 810 1
GENE REF ISO

Function

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Overview 
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.  
1
  • UniProtKB
GO molecular function 
Diacyl lipopeptide bindingdefinition[GO:0042498] silver  
1
  • Ortholog Compara
Lipopolysaccharide receptor activitydefinition[GO:0001875]  
1
  • UniProtKB
Lipoteichoic acid bindingdefinition[GO:0070891] silver  
1
  • Ortholog Compara
Peptidoglycan bindingdefinition[GO:0042834]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IntAct
  • UniProtKB
  • MTBbase
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • MGI
Receptor activitydefinition[GO:0004872]  
1
  • UniProtKB
Signaling pattern recognition receptor activitydefinition[GO:0008329]  
1
  • UniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888] silver  
1
  • InterPro 2 GO
Triacyl lipopeptide bindingdefinition[GO:0042497]  
1
  • MGI
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Cell surface pattern recognition receptor signaling pathwaydefinition[GO:0002752] silver  
1
  • Ortholog Compara
Cellular response to bacterial lipopeptidedefinition[GO:0071221]  
1
  • BHF-UCL
Cellular response to diacyl bacterial lipopeptidedefinition[GO:0071726]  
1
  • MGI
Cellular response to lipoteichoic aciddefinition[GO:0071223]  
1
  • MGI
Cellular response to peptidoglycandefinition[GO:0071224] silver  
1
  • Ortholog Compara
Cellular response to triacyl bacterial lipopeptidedefinition[GO:0071727]  
1
  • MGI
Central nervous system myelin formationdefinition[GO:0032289] silver  
1
  • Ortholog Compara
Chloramphenicol transportdefinition[GO:0042892] silver  
1
  • Ortholog Compara
Cytokine secretion involved in immune responsedefinition[GO:0002374] silver  
1
  • CACAO
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • UniProtKB
Detection of diacyl bacterial lipopeptidedefinition[GO:0042496]  
1
  • MGI
Detection of triacyl bacterial lipopeptidedefinition[GO:0042495]  
1
  • MGI
I-kappaB phosphorylationdefinition[GO:0007252]  
1
  • BHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • PINC
Induction by symbiont of defense-related host nitric oxide productiondefinition[GO:0052063] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • BHF-UCL
Interleukin-10 productiondefinition[GO:0032613] silver  
1
  • CACAO
Leukotriene metabolic processdefinition[GO:0006691] silver  
1
  • Ortholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • GOC
Microglial cell activationdefinition[GO:0001774] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
1
  • Ortholog Compara
Negative regulation of interleukin-12 productiondefinition[GO:0032695] silver  
1
  • Ortholog Compara
Negative regulation of interleukin-17 productiondefinition[GO:0032700] silver  
1
  • Ortholog Compara
Nitric oxide metabolic processdefinition[GO:0046209] silver  
1
  • Ortholog Compara
Positive regulation of chemokine productiondefinition[GO:0032722]  
1
  • BHF-UCL
Positive regulation of cytokine secretiondefinition[GO:0050715] silver  
1
  • Ortholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • BHF-UCL
Positive regulation of interferon-beta productiondefinition[GO:0032728]  
1
  • Ortholog Curator
Positive regulation of interleukin-10 productiondefinition[GO:0032733] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
1
  • Ortholog Curator
Positive regulation of interleukin-18 productiondefinition[GO:0032741]  
1
  • Ortholog Curator
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • BHF-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
2
  • BHF-UCL
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
1
  • Ortholog Compara
Positive regulation of macrophage cytokine productiondefinition[GO:0060907] silver  
1
  • Ortholog Compara
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
2
  • UniProtKB
  • MGI
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
1
  • Ortholog Compara
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
1
  • Ortholog Curator
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
1
  • Ortholog Compara
Positive regulation of toll-like receptor signaling pathwaydefinition[GO:0034123]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535] silver  
1
  • Ortholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • Ortholog Curator
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • BHF-UCL
Response to fatty aciddefinition[GO:0070542] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to molecule of fungal origindefinition[GO:0002238] silver  
1
  • Ortholog Compara
Response to progesteronedefinition[GO:0032570] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+7097  
Chagas disease (American trypanosomiasis)  hsa05142+7097  
Herpes simplex infection  hsa05168+7097  
Legionellosis  hsa05134+7097  
Leishmaniasis  hsa05140+7097  
Malaria  hsa05144+7097  
Measles  hsa05162+7097  
Phagosome  hsa04145+7097  
Rheumatoid arthritis  hsa05323+7097  
Toll-like receptor signaling pathway  hsa04620+7097  
Toxoplasmosis  hsa05145+7097  
Tuberculosis  hsa05152+7097  
According to Reactome, this protein belongs to the following pathways:
Beta defensins  REACT_115897  
MyD88:Mal cascade initiated on plasma membrane  REACT_6788  
Toll Like Receptor TLR1:TLR2 Cascade  REACT_8005  
Toll Like Receptor TLR6:TLR2 Cascade  REACT_8006  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TLR_2
GenomeRNAi: 7097
PRO: PR:O60603
Chemistry
GuidetoPHARMACOLOGY: 1752