TLR2 - Toll-like receptor 2 - human protein (Function)
 
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Protein
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TLR2 »  Toll-like receptor 2
 
Protein also known as:  Toll/interleukin-1 receptor-like protein 4; CD antigen CD282.
Gene name:  TLR2
Family name: Toll-like receptor
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 721 1
GENE REF ISO

Function

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Overview 
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.  
  • CuratedUniProtKB
GO molecular function 
Diacyl lipopeptide bindingdefinition[GO:0042498] silver  
  • IEAOrtholog Compara
Lipopolysaccharide receptor activitydefinition[GO:0001875]  
1
  • TASUniProtKB
Lipoteichoic acid bindingdefinition[GO:0070891] silver  
  • IEAOrtholog Compara
Peptidoglycan bindingdefinition[GO:0042834]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIUniProtKB
  • IPIIntAct
  • IPIMTBbase
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAMGI
Receptor activitydefinition[GO:0004872]  
1
  • IDAUniProtKB
Signaling pattern recognition receptor activitydefinition[GO:0008329]  
1
  • IDAUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888] silver  
  • IEAInterPro 2 GO
Triacyl lipopeptide bindingdefinition[GO:0042497]  
1
  • IDAMGI
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cell surface pattern recognition receptor signaling pathwaydefinition[GO:0002752] silver  
  • IEAOrtholog Compara
Cellular response to bacterial lipopeptidedefinition[GO:0071221]  
1
  • TASBHF-UCL
Cellular response to diacyl bacterial lipopeptidedefinition[GO:0071726]  
1
  • IDAMGI
Cellular response to lipoteichoic aciddefinition[GO:0071223]  
1
  • IDAMGI
Cellular response to peptidoglycandefinition[GO:0071224] silver  
  • IEAOrtholog Compara
Cellular response to triacyl bacterial lipopeptidedefinition[GO:0071727]  
1
  • IDAMGI
Central nervous system myelin formationdefinition[GO:0032289] silver  
  • IEAOrtholog Compara
Chloramphenicol transportdefinition[GO:0042892] silver  
  • IEAOrtholog Compara
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • IDAUniProtKB
Detection of diacyl bacterial lipopeptidedefinition[GO:0042496]  
1
  • IDAMGI
Detection of triacyl bacterial lipopeptidedefinition[GO:0042495]  
1
  • IDAMGI
I-kappaB phosphorylationdefinition[GO:0007252]  
1
  • IDABHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Induction by symbiont of defense-related host nitric oxide productiondefinition[GO:0052063] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • TASBHF-UCL
Leukotriene metabolic processdefinition[GO:0006691] silver  
  • IEAOrtholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • TASGOC
Microglial cell activation involved in immune responsedefinition[GO:0002282] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-12 productiondefinition[GO:0032695] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-17 productiondefinition[GO:0032700] silver  
  • IEAOrtholog Compara
Nitric oxide metabolic processdefinition[GO:0046209] silver  
  • IEAOrtholog Compara
Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responsedefinition[GO:0052033] silver  
  • IEAOrtholog Compara
Positive regulation of chemokine productiondefinition[GO:0032722]  
1
  • IDABHF-UCL
Positive regulation of cytokine secretiondefinition[GO:0050715] silver  
  • IEAOrtholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interferon-beta productiondefinition[GO:0032728]  
  • ISSOrtholog Curator
Positive regulation of interleukin-10 productiondefinition[GO:0032733] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
  • ISSOrtholog Curator
Positive regulation of interleukin-18 productiondefinition[GO:0032741]  
  • ISSOrtholog Curator
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IDABHF-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
2
  • IDABHF-UCL
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
  • IEAOrtholog Compara
Positive regulation of macrophage cytokine productiondefinition[GO:0060907] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAMGI
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
  • IEAOrtholog Compara
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
  • ISSOrtholog Curator
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
  • IEAOrtholog Compara
Positive regulation of toll-like receptor signaling pathwaydefinition[GO:0034123]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535] silver  
  • IEAOrtholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
  • ISSOrtholog Curator
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IMPBHF-UCL
Response to fatty aciddefinition[GO:0070542] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to molecule of fungal origindefinition[GO:0002238] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+7097  
Chagas disease (American trypanosomiasis)  hsa05142+7097  
Herpes simplex infection  hsa05168+7097  
Legionellosis  hsa05134+7097  
Leishmaniasis  hsa05140+7097  
Malaria  hsa05144+7097  
Measles  hsa05162+7097  
Phagosome  hsa04145+7097  
Rheumatoid arthritis  hsa05323+7097  
Toll-like receptor signaling pathway  hsa04620+7097  
Toxoplasmosis  hsa05145+7097  
Tuberculosis  hsa05152+7097  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TLR_2
GenomeRNAi: 7097
PRO: PR:O60603
Chemistry
GuidetoPHARMACOLOGY: 1752