LMX1B - LIM homeobox transcription factor 1-beta - human protein (Function)
 
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LMX1B »  LIM homeobox transcription factor 1-beta
 
Protein also known as:  LIM/homeobox protein LMX1B.
Gene name:  LMX1B
Entry whose protein(s) existence is based on evidence at protein level
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1 37 3
GENE REF ISO

Function

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Overview 
Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell deathdefinition[GO:0008219] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
  • IEAOrtholog Compara
Cerebellum morphogenesisdefinition[GO:0021587] silver  
  • IEAOrtholog Compara
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
1
  • NASUniProtKB
Limb morphogenesisdefinition[GO:0035108] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
3
  • NASUniProtKB
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Trabecular meshwork developmentdefinition[GO:0002930] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LMX1B
GenomeRNAi: 4010
PRO: PR:O60663