ABCC9 - ATP-binding cassette sub-family C member 9 - human protein (Function)
 
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ABCC9 »  ATP-binding cassette sub-family C member 9
 
Protein also known as:  Sulfonylurea receptor 2.
Gene name:  ABCC9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 41 2
GENE REF ISO

Function

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Overview 
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.23  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Potassium channel activitydefinition[GO:0005267] silver  
  • IEAOrtholog Compara
Potassium channel regulator activitydefinition[GO:0015459]  
  • ISSOrtholog Curator
Sulfonylurea receptor activitydefinition[GO:0008281]  
  • ISSOrtholog Curator
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Defense response to virusdefinition[GO:0051607]  
1
  • IMPMGI
Potassium ion importdefinition[GO:0010107]  
  • ISSOrtholog Curator
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+10060  
According to Reactome, this protein belongs to the following pathways:
ABC-family proteins mediated transport  REACT_15480  
ATP sensitive Potassium channels  REACT_75775  
Note 
May contribute to the regulation of sleep duration. An intronic variant of this gene may account for about 5% of the variation of sleep duration between individuals (PubMed22105623). Sleep duration is influenced both by environmental and genetic factors, with an estimated heritability of about 40%. Numerous genes are expected to contribute to the regulation of sleep duration.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCC9
GenomeRNAi: 10060
PRO: PR:O60706