ICMT - Protein-S-isoprenylcysteine O-methyltransferase - human protein (Function)
 
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ICMT »  Protein-S-isoprenylcysteine O-methyltransferase   [ EC 2.1.1.100 ]
 
Protein also known as:  Prenylated protein carboxyl methyltransferase (PPMT).
Gene name:  ICMT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.  
  • CuratedUniProtKB
GO molecular function 
cAMP response element binding protein bindingdefinition[GO:0008140] silver  
  • IEAOrtholog Compara
Protein C-terminal carboxyl O-methyltransferase activitydefinition[GO:0003880]  
1
  • TASPINC
Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activitydefinition[GO:0004671]  
  • IEAEC 2 GO
GO biological process 
C-terminal protein methylationdefinition[GO:0006481]  
1
  • TASPINC
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Protein targeting to membranedefinition[GO:0006612]  
1
  • TASPINC
Regulation of Ras protein signal transductiondefinition[GO:0046578] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.100: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.  
  • CuratedUniProtKB
It requires the following cofactor
Divalent cations. Probably zinc (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O60725
Other
GeneWiki: ICMT
GenomeRNAi: 23463
PRO: PR:O60725