HCN1 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 - human protein (Function)
 
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HCN1 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
 
Protein also known as:  Brain cyclic nucleotide-gated channel 1 (BCNG-1).
Gene name:  HCN1
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at transcript level
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1 42 1
GENE REF ISO

Function

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Overview 
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.  
1
  • CuratedUniProtKB
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
  • ISSOrtholog Curator
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
  • ISSOrtholog Curator
Potassium channel activitydefinition[GO:0005267]  
1
  • NASUniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • IMPUniProtKB
  • IBARefGenome
  • ISSOrtholog Curator
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IMPUniProtKB
GO biological process 
Apical protein localizationdefinition[GO:0045176] silver  
  • IEAOrtholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IMPUniProtKB
  • IBARefGenome
  • ISSOrtholog Curator
Potassium ion transportdefinition[GO:0006813]  
1
  • NASUniProtKB
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPUniProtKB
  • IBARefGenome
Retinal cone cell developmentdefinition[GO:0046549] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. CAMP binding promotes tetramerization and formation of an active channel. Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low. Inhibited by Cs(1+), zatebradine, capsazepine and ZD7288.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN1
GenomeRNAi: 348980
PRO: PR:O60741
Chemistry
GuidetoPHARMACOLOGY: 400