CCDC22 - Coiled-coil domain-containing protein 22 - human protein (Function)
 
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CCDC22 »  Coiled-coil domain-containing protein 22
 
Gene name:  CCDC22
Family name: CCDC22
Entry whose protein(s) existence is based on evidence at protein level
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1 21 1
GENE REF ISO

Function

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Overview 
Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via assocation with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed25355947).  
3
  • UniProtKB
GO molecular function 
Cullin family protein bindingdefinition[GO:0097602]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
GO biological process 
Cellular copper ion homeostasisdefinition[GO:0006878]  
1
  • UniProtKB
Cytoplasmic sequestering of NF-kappaBdefinition[GO:0007253]  
1
  • UniProtKB
Golgi to plasma membrane transportdefinition[GO:0006893]  
1
  • UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • UniProtKB
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 28952
PRO: PR:O60826