PQBP1 - Polyglutamine-binding protein 1 - human protein (Function)
 
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Protein
Gene
References

 
PQBP1 »  Polyglutamine-binding protein 1  (PQBP-1)
 
Protein also known as:  38 kDa nuclear protein containing a WW domain (Npw38).
Gene name:  PQBP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.  
3
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • IDAMGI
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
GO biological process 
Regulation of RNA splicingdefinition[GO:0043484]  
1
  • IMPMGI
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PQBP1
GenomeRNAi: 10084
PRO: PR:O60828