DKC1 - H/ACA ribonucleoprotein complex subunit 4 - human protein (Function)
 
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DKC1 »  H/ACA ribonucleoprotein complex subunit 4   [ EC 5.4.99.- ]
 
Protein also known as:  Nopp140-associated protein of 57 kDa.
Gene name:  DKC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 2
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.  
1
  • UniProtKB
Isoform  Iso 3   Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).  
1
  • UniProtKB
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Pseudouridine synthase activitydefinition[GO:0009982]  
1
  • RefGenome
RNA bindingdefinition[GO:0003723]  
1
  • PINC
Telomerase activitydefinition[GO:0003720]  
1
  • UniProtKB
GO biological process 
Box H/ACA snoRNA 3'-end processingdefinition[GO:0000495]  
1
  • RefGenome
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
mRNA pseudouridine synthesisdefinition[GO:1990481]  
1
  • RefGenome
Positive regulation of telomerase activitydefinition[GO:0051973] silver  
1
  • Ortholog Compara
Positive regulation of telomere maintenance via telomerasedefinition[GO:0032212] silver  
1
  • Ortholog Compara
RNA processingdefinition[GO:0006396]  
1
  • PINC
rRNA processingdefinition[GO:0006364]  
1
  • PINC
rRNA pseudouridine synthesisdefinition[GO:0031118]  
1
  • RefGenome
snRNA pseudouridine synthesisdefinition[GO:0031120]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.4.99.-: RNA uridine RNA pseudouridine.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ribosome biogenesis in eukaryotes  hsa03008+1736  
According to Reactome, this protein belongs to the following pathway:
Telomere Extension By Telomerase  R-HSA-171319  
 

Keywords

Biological process 
Ribosome biogenesis  definition   [KW-0690]
rRNA processing  definition   [KW-0698]
Molecular function 
Isomerase  definition   [KW-0413]
Ribonucleoprotein  definition   [KW-0687]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dyskerin
GenomeRNAi: 1736
PRO: PR:O60832