CACNA1F - Voltage-dependent L-type calcium channel subunit alpha-1F - human protein (Function)
 
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CACNA1F »  Voltage-dependent L-type calcium channel subunit alpha-1F
 
Protein also known as:  Voltage-gated calcium channel subunit alpha Cav1.4.
Gene name:  CACNA1F
Entry whose protein(s) existence is based on evidence at protein level
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1 58 3
GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.11.11  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • IDAUniProtKB
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Detection of light stimulus involved in visual perceptiondefinition[GO:0050908]  
1
  • IMPUniProtKB
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601]  
3
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+778  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+778  
Calcium signaling pathway  hsa04020+778  
Cardiac muscle contraction  hsa04260+778  
Cholinergic synapse  hsa04725+778  
Dilated cardiomyopathy  hsa05414+778  
GABAergic synapse  hsa04727+778  
GnRH signaling pathway  hsa04912+778  
Hypertrophic cardiomyopathy (HCM)  hsa05410+778  
MAPK signaling pathway  hsa04010+778  
Vascular smooth muscle contraction  hsa04270+778  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cav1.4
GenomeRNAi: 778
PRO: PR:O60840
Chemistry
GuidetoPHARMACOLOGY: 531