DIAPH2 - Protein diaphanous homolog 2 - human protein (Function)
 
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DIAPH2 »  Protein diaphanous homolog 2
 
Protein also known as:  Diaphanous-related formin-2 (DRF2).
Gene name:  DIAPH2
Family name: Formin homology » Diaphanous
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 3
GENE REF ISO

Function

 show evidences
Overview 
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
Rho GTPase bindingdefinition[GO:0017048] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin filament polymerizationdefinition[GO:0030041] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Cytokinesisdefinition[GO:0000910]  
1
  • TASPINC
Female gamete generationdefinition[GO:0007292]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Oogenesisdefinition[GO:0048477]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+1730  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Oogenesis  definition   [KW-0896]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DIAPH2
GenomeRNAi: 1730
PRO: PR:O60879