SH2D1A - SH2 domain-containing protein 1A - human protein (Function)
 
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Protein
Gene
References

 
SH2D1A »  SH2 domain-containing protein 1A
 
Protein also known as:  Signaling lymphocytic activation molecule-associated protein (SLAM-associated protein).
Gene name:  SH2D1A
Entry whose protein(s) existence is based on evidence at protein level
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1 94 6
GENE REF ISO

Function

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Overview 
Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
12
  • IntAct
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • UniProtKB
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • UniProtKB
Cellular defense responsedefinition[GO:0006968]  
1
  • UniProtKB
Humoral immune responsedefinition[GO:0006959] silver  
1
  • Ortholog Compara
Positive regulation of natural killer cell mediated cytotoxicitydefinition[GO:0045954] silver  
1
  • Ortholog Compara
Positive regulation of signal transductiondefinition[GO:0009967]  
2
  • GOC
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Measles  hsa05162+4068  
Natural killer cell mediated cytotoxicity  hsa04650+4068  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SH2D1A
GenomeRNAi: 4068
PRO: PR:O60880