MMP20 - Matrix metalloproteinase-20 - human protein (Function)
 
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MMP20 »  Matrix metalloproteinase-20   [ EC 3.4.24.- ]  (MMP-20)
 
Protein also known as:  Enamel metalloproteinase.
Gene name:  MMP20
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Amelogenesisdefinition[GO:0097186] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Regulation of enamel mineralizationdefinition[GO:0070173]  
1
  • TASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves aggrecan at the 360-Asn-|-Phe-361 site.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 2 zinc ions per subunit.  
1
  • CuratedUniProtKB
Binds 2 calcium ions per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP20
GenomeRNAi: 9313
PRO: PR:O60882