MMP20 - Matrix metalloproteinase-20 - human protein (Sequence)
 
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Protein
Gene
References

 
MMP20 »  Matrix metalloproteinase-20   [ EC 3.4.24.- ]  (MMP-20)
 
Protein also known as:  Enamel metalloproteinase.
Gene name:  MMP20
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   483 aaMass: 54387 Da,  pI: 8.92
MKVLPASGLA VFLIMALKFS TAAPSLVAAS PRTWRNNYRL AQAYLDKYYT NKEGHQIGEM VARGSNSMIR KIKELQAFFG LQVTGKLDQT TMNVIKKPRC GVPDVANYRL FPGEPKWKKN TLTYRISKYT PSMSSVEVDK AVEMALQAWS SAVPLSFVRI NSGEADIMIS FENGDHGDSY PFDGPRGTLA HAFAPGEGLG GDTHFDNAEK WTMGTNGFNL FTVAAHEFGH ALGLAHSTDP SALMYPTYKY KNPYGFHLPK DDVKGIQALY GPRKVFLGKP TLPHAPHHKP SIPDLCDSSS SFDAVTMLGK ELLLFKDRIF WRRQVHLRTG IRPSTITSSF PQLMSNVDAA YEVAERGTAY FFKGPHYWIT RGFQMQGPPR TIYDFGFPRH VQQIDAAVYL REPQKTLFFV GDEYYSYDER KRKMEKDYPK NTEEEFSGVN GQIDAAVELN GYIYFFSGPK TYKYDTEKED VVSVVKSSSW IGC

Sequence

 show evidences
Domain 
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.  
  • CuratedUniProtKB
PTM 
Autoactivates at least at the 107-Asn-|-Tyr-108 site (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
Signal  definition   [KW-0732]
PTM 
Autocatalytic cleavage  definition   [KW-0068]
Disulfide bond  definition   [KW-1015]
Zymogen  definition   [KW-0865]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.110.10.10
Gene3D: 3.40.390.10
InterPro: IPR021190 [ Pept M10A ]
InterPro: IPR021158 [ Pept M10A Zn BS ]
InterPro: IPR016293 [ Pept M10A stromelysin-type ]
InterPro: IPR002477 [ Peptidoglycan-bd-like ]
InterPro: IPR006026 [ Peptidase Metallo ]
InterPro: IPR000585 [ Hemopexin-like dom ]
InterPro: IPR018487 [ Hemopexin-like repeat ]
InterPro: IPR001818 [ Pept M10 metallopeptidase ]
InterPro: IPR024079 [ MetalloPept cat dom ]
PANTHER: PTHR10201 [ PTHR10201 ]
PANTHER: PTHR10201:SF35 [ PTHR10201:SF35 ]
Pfam: PF00413 [ Peptidase M10 ]
Pfam: PF00045 [ Hemopexin ]
Pfam: PF01471 [ PG binding 1 ]
PIRSF: PIRSF001191 [ Peptidase M10A matrix ]
PRINTS: PR00138 [ MATRIXIN ]
PROSITE: PS00546 [ CYSTEINE SWITCH ]
PROSITE: PS51642 [ HEMOPEXIN 2 ]
PROSITE: PS00142 [ ZINC PROTEASE ]
SMART: SM00235 [ ZnMc ]
SMART: SM00120 [ HX ]
SUPFAM: SSF47090 [ SSF47090 ]
SUPFAM: SSF50923 [ SSF50923 ]
Genome annotation databases
Ensembl: Transcript: ENST00000260228;  Protein: ENSP00000260228;  Gene: ENSG00000137674.
KEGG: hsa:9313
UCSC: uc001phc.3
Organism-specific databases
MGI: MGI:1353466 [ Mmp20 ]
Other
EvolutionaryTrace: O60882
PTM databases
PhosphoSite: O60882
Phylogenomic databases
eggNOG: NOG328389
HOGENOM: HOG000217927
HOVERGEN: HBG052484
InParanoid: O60882
KO: K07999
OMA: PDVANYR
OrthoDB: EOG7XPZ57
PhylomeDB: O60882
Sequence databases
CCDS: CCDS8318.1 [ O60882-1 ]
EMBL: Genomic DNA:  AY673603 . Translation:  AAT70722.1 .
EMBL: Genomic DNA:  AP000851 . No translation available.
EMBL: mRNA:  Y12779 . Translation:  CAA73317.1 .
IPI: IPI00032404
RefSeq: Protein:  NP_004762.2. Nucleotide sequence:  NM_004771.3.
UniProtKB: O60882
Protocols and materials databases
DNASU: 9313