GPR37L1 - Prosaposin receptor GPR37L1 - human protein (Function)
 
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Protein
Gene
References

 
GPR37L1 »  Prosaposin receptor GPR37L1
 
Protein also known as:  Endothelin B receptor-like protein 2 (ETBR-LP-2).
Gene name:  GPR37L1
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.  
2
  • UniProtKB
GO molecular function 
G-protein coupled peptide receptor activitydefinition[GO:0008528]  
1
  • ParkinsonsUK-UCL
Peptide bindingdefinition[GO:0042277]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
2
  • ParkinsonsUK-UCL
  • IntAct
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • ParkinsonsUK-UCL
Negative regulation of astrocyte differentiationdefinition[GO:0048712] silver  
1
  • Ortholog Compara
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
1
  • ParkinsonsUK-UCL
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
1
  • Ortholog Compara
Positive regulation of cerebellar granule cell precursor proliferationdefinition[GO:0021940] silver  
1
  • Ortholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • ParkinsonsUK-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR37L1
GenomeRNAi: 9283
PRO: PR:O60883
Chemistry
GuidetoPHARMACOLOGY: 104