BRD4 - Bromodomain-containing protein 4 - human protein (Function)
 
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BRD4 »  Bromodomain-containing protein 4
 
Protein also known as:  Protein HUNK1.
Gene name:  BRD4
Entry whose protein(s) existence is based on evidence at protein level
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1 141 3
GENE REF ISO

Function

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Overview 
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
4
  • UniProtKB
DNA bindingdefinition[GO:0003677] silver  
1
  • Ortholog Compara
Lysine-acetylated histone bindingdefinition[GO:0070577]  
4
  • UniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • UniProtKB
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
2
  • UniProtKB
  • UniProtKB KW
Isoform  B   Chromatin remodelingdefinition[GO:0006338]  
1
  • UniProtKB
Chromosome segregationdefinition[GO:0007059] silver  
1
  • Ortholog Compara
Histone H3-K14 acetylationdefinition[GO:0044154] silver  
1
  • Ortholog Compara
Histone H4-K12 acetylationdefinition[GO:0043983] silver  
1
  • Ortholog Compara
Inner cell mass cell proliferationdefinition[GO:0001833] silver  
1
  • Ortholog Compara
Isoform  B   Negative regulation of DNA damage checkpointdefinition[GO:2000002]  
1
  • UniProtKB
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
1
  • Ortholog Compara
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971]  
1
  • MGI
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoterdefinition[GO:0032968]  
3
  • UniProtKB
  • MGI
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • UniProtKB
Regulation of phosphorylation of RNA polymerase II C-terminal domaindefinition[GO:1901407]  
1
  • UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0000083]  
1
  • MGI
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BRD4
GenomeRNAi: 23476
PRO: PR:O60885
Chemistry
GuidetoPHARMACOLOGY: 1945