CTSV - Cathepsin L2 - human protein (Function)
 
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CTSV »  Cathepsin L2   [ EC 3.4.22.43 ]
 
Protein also known as:  Cathepsin U.
Gene name:  CTSV
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cysteine protease. May have an important role in corneal physiology.  
2
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177] silver  
  • IEAOrtholog Compara
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAOrtholog Compara
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Kininogen bindingdefinition[GO:0030984] silver  
  • IEAOrtholog Compara
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
Autophagic cell deathdefinition[GO:0048102] silver  
  • IEAOrtholog Compara
Cellular response to starvationdefinition[GO:0009267] silver  
  • IEAOrtholog Compara
Decidualizationdefinition[GO:0046697] silver  
  • IEAOrtholog Compara
Multicellular organismal agingdefinition[GO:0010259] silver  
  • IEAOrtholog Compara
Nerve developmentdefinition[GO:0021675] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to gonadotropindefinition[GO:0034698] silver  
  • IEAOrtholog Compara
Sertoli cell differentiationdefinition[GO:0060008] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.43: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1515  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Immune System  REACT_6900  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O60911
Other
GeneWiki: Cathepsin_L2
GenomeRNAi: 1515
PRO: PR:O60911