CTNS - Cystinosin - human protein (Function)
 
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Protein
Gene
References

 
CTNS »  Cystinosin
 
Gene name:  CTNS
Family name: Cystinosin
Entry whose protein(s) existence is based on evidence at protein level
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1 55 2
GENE REF ISO

Function

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Overview 
Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the lysosomal cystine transporter (lct) family  2.A.43.1.1  
GO molecular function 
L-cystine transmembrane transporter activitydefinition[GO:0015184]  
2
  • UniProtKB
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
1
  • Ortholog Compara
ATP metabolic processdefinition[GO:0046034]  
1
  • UniProtKB
Brain developmentdefinition[GO:0007420]  
1
  • UniProtKB
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • UniProtKB
Cognitiondefinition[GO:0050890]  
1
  • UniProtKB
Glutathione metabolic processdefinition[GO:0006749]  
1
  • UniProtKB
Grooming behaviordefinition[GO:0007625] silver  
1
  • Ortholog Compara
L-cystine transportdefinition[GO:0015811]  
4
  • MGI
  • UniProtKB
Lens development in camera-type eyedefinition[GO:0002088] silver  
1
  • Ortholog Compara
Long-term memorydefinition[GO:0007616] silver  
1
  • Ortholog Compara
Melanin biosynthetic processdefinition[GO:0042438]  
1
  • UniProtKB KW
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1497  
 

Keywords

Biological process 
Melanin biosynthesis  definition   [KW-0470]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CTNS_(gene)
GenomeRNAi: 1497
PRO: PR:O60931