SCN2B - Sodium channel subunit beta-2 - human protein (Function)
 
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SCN2B »  Sodium channel subunit beta-2
 
Gene name:  SCN2B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the na(+) channel auxiliary subunit 1-4 (sca-) family  8.A.17.2.1  
GO molecular function 
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • IDABHF-UCL
Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialdefinition[GO:0086006]  
1
  • IMPBHF-UCL
GO biological process 
Cardiac muscle cell action potential involved in contractiondefinition[GO:0086002]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • IMPGOC
Nervous system developmentdefinition[GO:0007399] silver  
  • IEAOrtholog Compara
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
1
  • IMPBHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of sodium ion transmembrane transporter activitydefinition[GO:2000649]  
1
  • IDABHF-UCL
Response to pyrethroiddefinition[GO:0046684] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDABHF-UCL
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCN2B
GenomeRNAi: 6327
PRO: PR:O60939