NOS1AP - Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein - human protein (Function)
 
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NOS1AP »  Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
 
Protein also known as:  C-terminal PDZ ligand of neuronal nitric oxide synthase protein.
Gene name:  NOS1AP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).  
1
  • UniProtKB
GO molecular function 
Nitric-oxide synthase bindingdefinition[GO:0050998]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Positive regulation of delayed rectifier potassium channel activitydefinition[GO:1902261]  
1
  • BHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • BHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • BHF-UCL
Positive regulation of nitric oxide mediated signal transductiondefinition[GO:0010750]  
1
  • BHF-UCL
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • BHF-UCL
Positive regulation of peptidyl-cysteine S-nitrosylationdefinition[GO:2000170]  
1
  • BHF-UCL
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381]  
1
  • BHF-UCL
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationdefinition[GO:1903762]  
1
  • BHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • DFLAT
Regulation of cardiac muscle cell action potentialdefinition[GO:0098901]  
2
  • BHF-UCL
Regulation of generation of L-type calcium currentdefinition[GO:1902514]  
2
  • BHF-UCL
Regulation of heart rate by chemical signaldefinition[GO:0003062]  
1
  • BHF-UCL
Regulation of high voltage-gated calcium channel activitydefinition[GO:1901841]  
2
  • BHF-UCL
Regulation of nitric oxide biosynthetic processdefinition[GO:0045428]  
1
  • DFLAT
Regulation of nitric-oxide synthase activitydefinition[GO:0050999]  
1
  • DFLAT
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
2
  • BHF-UCL
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOS1AP
GenomeRNAi: 9722
PRO: PR:O75052