CBFA2T3 - Protein CBFA2T3 - human protein (Function)
 
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CBFA2T3 »  Protein CBFA2T3
 
Protein also known as:  Myeloid translocation gene on chromosome 16 protein.
Gene name:  CBFA2T3
Family name: CBFA2T
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed12559562, PubMed15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed23840896, PubMed25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed15231665).  
10
  • UniProtKB
Isoform  Iso 2   Functions as an A-kinase-anchoring protein (PubMed11823486).  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
Transcription corepressor activitydefinition[GO:0003714]  
3
  • UniProtKB
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700] silver  
1
  • InterPro 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Granulocyte differentiationdefinition[GO:0030851]  
1
  • MGI
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of glycolytic processdefinition[GO:0045820]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
4
  • UniProtKB
  • RefGenome
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • UniProtKB
Regulation of aerobic respirationdefinition[GO:1903715]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CBFA2T3
GenomeRNAi: 863
PRO: PR:O75081