FZD7 - Frizzled-7 - human protein (Function)
 
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FZD7 »  Frizzled-7  (Fz-7)
 
Protein also known as:  FzE3.
Gene name:  FZD7
Entry whose protein(s) existence is based on evidence at protein level
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1 34 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147]  
1
  • IPIBHF-UCL
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IBARefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
4
  • IDAUniProtKB
  • IMPBHF-UCL
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Mesenchymal to epithelial transitiondefinition[GO:0060231]  
1
  • IMPBHF-UCL
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
1
  • IMPBHF-UCL
Negative regulation of ectodermal cell fate specificationdefinition[GO:0042666]  
1
  • IMPBHF-UCL
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Non-canonical Wnt signaling pathway via JNK cascadedefinition[GO:0038031]  
1
  • IMPBHF-UCL
Positive regulation of epithelial cell proliferation involved in wound healingdefinition[GO:0060054]  
1
  • IMPBHF-UCL
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • ICBHF-UCL
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IMPBHF-UCL
Regulation of catenin import into nucleusdefinition[GO:0035412]  
1
  • IMPBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPBHF-UCL
Satellite cell maintenance involved in skeletal muscle regenerationdefinition[GO:0014834] silver  
  • IEAOrtholog Compara
Somatic stem cell divisiondefinition[GO:0048103] silver  
  • IEAOrtholog Compara
Stem cell maintenancedefinition[GO:0019827]  
1
  • IMPBHF-UCL
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8324  
HTLV-I infection  hsa05166+8324  
Melanogenesis  hsa04916+8324  
Pathways in cancer  hsa05200+8324  
Wnt signaling pathway  hsa04310+8324  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD7
GenomeRNAi: 8324
PRO: PR:O75084