AOC2 - Retina-specific copper amine oxidase - human protein (Function)
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AOC2 »  Retina-specific copper amine oxidase   [ EC ]  (RAO)
Protein also known as:  Semicarbazide-sensitive amine oxidase (SSAO).
Gene name:  AOC2
Entry whose protein(s) existence is based on evidence at protein level
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Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.  
  • CuratedUniProtKB
GO molecular function 
Aliphatic-amine oxidase activitydefinition[GO:0052595]  
  • IEAEC 2 GO
Aminoacetone:oxygen oxidoreductase(deaminating) activitydefinition[GO:0052594]  
  • IEAEC 2 GO
Copper ion bindingdefinition[GO:0005507] silver  
  • IEAInterPro 2 GO
Electron carrier activitydefinition[GO:0009055]  
  • TASUniProtKB
Phenethylamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052596]  
  • IEAEC 2 GO
Primary amine oxidase activitydefinition[GO:0008131]  
  • IEAEC 2 GO
Quinone bindingdefinition[GO:0048038] silver  
  • IEAInterPro 2 GO
Tryptamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052593]  
  • IEAEC 2 GO
GO biological process 
Amine metabolic processdefinition[GO:0009308] silver  
  • IEAInterPro 2 GO
Catecholamine metabolic processdefinition[GO:0006584]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC RCH(2)NH(2) + H(2)O + O(2) RCHO + NH(3) + H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 copper ion per subunit (By similarity).  
  • CuratedUniProtKB
Binds 2 calcium ions per subunit (By similarity).  
  • CuratedUniProtKB
Contains 1 topaquinone per subunit (By similarity).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+314  
Glycine, serine and threonine metabolism  hsa00260+314  
Metabolic pathways  hsa01100+314  
Phenylalanine metabolism  hsa00360+314  
Tyrosine metabolism  hsa00350+314  

Biophysicochemical properties

Kinetic parameters
KM 0.178 mM for p-tyramine
KM 0.077 mM for 2-phenylethylamine
KM 1.7 mM for methylamine
KM 0.056 mM for tryptamine
KM 0.167 mM for benzylamine


Biological process 
Catecholamine metabolism  definition   [KW-0128]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: O75106
GenomeRNAi: 314
PRO: PR:O75106