ROCK2 - Rho-associated protein kinase 2 - human protein (Function)
 
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ROCK2 »  Rho-associated protein kinase 2   [ EC 2.7.11.1 ]
 
Protein also known as:  Rho-associated, coiled-coil-containing protein kinase II (ROCK-II).
Gene name:  ROCK2
Entry whose protein(s) existence is based on evidence at protein level
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1 114 1
GENE REF ISO

Function

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Overview 
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.  
9
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • UniProtKB
Rho GTPase bindingdefinition[GO:0017048] silver  
1
  • InterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • PINC
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Centrosome duplicationdefinition[GO:0051298]  
1
  • UniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • PINC
Dendrite morphogenesisdefinition[GO:0048813] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625] silver  
1
  • Ortholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • UniProtKB
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Positive regulation of centrosome duplicationdefinition[GO:0010825] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • UniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • UniProtKB
Regulation of circadian rhythmdefinition[GO:0042752]  
1
  • Ortholog Curator
Regulation of establishment of cell polaritydefinition[GO:2000114]  
1
  • UniProtKB
Regulation of focal adhesion assemblydefinition[GO:0051893]  
1
  • UniProtKB
Regulation of keratinocyte differentiationdefinition[GO:0045616]  
1
  • UniProtKB
Regulation of stress fiber assemblydefinition[GO:0051492]  
1
  • UniProtKB
Rho protein signal transductiondefinition[GO:0007266] silver  
1
  • InterPro 2 GO
Rhythmic processdefinition[GO:0048511]  
1
  • UniProtKB KW
Smooth muscle contractiondefinition[GO:0006939]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by RHOA binding. Inhibited by Y-27632 (By similarity).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+9475  
Chemokine signaling pathway  hsa04062+9475  
Focal adhesion  hsa04510+9475  
Leukocyte transendothelial migration  hsa04670+9475  
Pathogenic Escherichia coli infection  hsa05130+9475  
Regulation of actin cytoskeleton  hsa04810+9475  
Salmonella infection  hsa05132+9475  
Shigellosis  hsa05131+9475  
TGF-beta signaling pathway  hsa04350+9475  
Vascular smooth muscle contraction  hsa04270+9475  
Wnt signaling pathway  hsa04310+9475  
According to Reactome, this protein belongs to the following pathways:
EPHA-mediated growth cone collapse  REACT_264548  
EPHB-mediated forward signaling  REACT_263952  
G alpha (12/13) signalling events  REACT_18407  
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 9475
PRO: PR:O75116
Chemistry
GuidetoPHARMACOLOGY: 1504