ICOSLG - ICOS ligand - human protein (Function)
 
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Protein
Gene
References

 
ICOSLG »  ICOS ligand
 
Protein also known as:  B7-related protein 1 (B7RP-1); CD antigen CD275.
Gene name:  ICOSLG
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
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1 46 3
GENE REF ISO

Function

 show evidences
Overview 
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Receptor bindingdefinition[GO:0005102]  
1
  • TASUniProtKB
GO biological process 
B cell activationdefinition[GO:0042113]  
  • IEAUniProtKB KW
Defense responsedefinition[GO:0006952]  
1
  • NASUniProtKB
Hyperosmotic responsedefinition[GO:0006972]  
1
  • NASUniProtKB
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • TASUniProtKB
Positive regulation of interleukin-4 biosynthetic processdefinition[GO:0045404] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
T cell activationdefinition[GO:0042110]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+23308  
Intestinal immune network for IgA production  hsa04672+23308  
According to Reactome, this protein belongs to the following pathway:
Costimulation by the CD28 family  REACT_19344  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
B-cell activation  definition   [KW-0075]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ICOSLG
GenomeRNAi: 23308
PRO: PR:O75144