HIP1R - Huntingtin-interacting protein 1-related protein - human protein (Function)
 
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References

 
HIP1R »  Huntingtin-interacting protein 1-related protein  (HIP1-related protein)
 
Protein also known as:  Huntingtin-interacting protein 12 (HIP-12).
Gene name:  HIP1R
Family name: SLA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 32 2
GENE REF ISO

Function

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Overview 
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Phosphatidylinositol bindingdefinition[GO:0035091]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HIP1R
GenomeRNAi: 9026
PRO: PR:O75146