OBSL1 - Obscurin-like protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
OBSL1 »  Obscurin-like protein 1
 
Gene name:  OBSL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 4
GENE REF ISO

Function

 show evidences
Overview 
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed24793695, PubMed24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.  
2
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • NASBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Cardiac myofibril assemblydefinition[GO:0055003]  
1
  • NASBHF-UCL
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • NASBHF-UCL
Golgi organizationdefinition[GO:0007030]  
1
  • IMPUniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • IMPUniProtKB
Positive regulation of dendrite morphogenesisdefinition[GO:0050775]  
1
  • IMPUniProtKB
Protein localization to Golgi apparatusdefinition[GO:0034067]  
1
  • IMPUniProtKB
Regulation of mitosisdefinition[GO:0007088]  
1
  • IMPUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OBSL1
GenomeRNAi: 23363
PRO: PR:O75147