SOCS5 - Suppressor of cytokine signaling 5 - human protein (Function)
 
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SOCS5 »  Suppressor of cytokine signaling 5  (SOCS-5)
 
Protein also known as:  Cytokine-inducible SH2-containing protein 5.
Gene name:  SOCS5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

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Overview 
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.  
1
  • CuratedUniProtKB
GO molecular function 
Epidermal growth factor receptor bindingdefinition[GO:0005154] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IPIUniProtKB
GO biological process 
Cell growthdefinition[GO:0016049]  
1
  • NASUniProtKB
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • ISSOrtholog Curator
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173] silver  
  • IEAOrtholog Compara
JAK-STAT cascadedefinition[GO:0007259] silver  
  • IEAInterPro 2 GO
Negative regulation of epidermal growth factor-activated receptor activitydefinition[GO:0007175]  
1
  • IDAUniProtKB
Negative regulation of signal transductiondefinition[GO:0009968]  
1
  • NASUniProtKB
Negative regulation of T-helper 2 cell differentiationdefinition[GO:0045629]  
  • ISSOrtholog Curator
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IMPUniProtKB
Positive regulation of T-helper 1 cell differentiationdefinition[GO:0045627]  
  • ISSOrtholog Curator
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Regulation of growthdefinition[GO:0040008]  
  • IEAUniProtKB KW
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Jak-STAT signaling pathway  hsa04630+9655  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOCS5
GenomeRNAi: 9655
PRO: PR:O75159