ADAMTS4 - A disintegrin and metalloproteinase with thrombospondin motifs 4 - human protein (Function)
 
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ADAMTS4 »  A disintegrin and metalloproteinase with thrombospondin motifs 4   [ EC 3.4.24.82 ]  (ADAMTS-4)
 
Protein also known as:  Aggrecanase-1.
Gene name:  ADAMTS4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.  
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  • UniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
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  • Ortholog Compara
Metallopeptidase activitydefinition[GO:0008237]  
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  • PINC
Peptidase activitydefinition[GO:0008233]  
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  • PINC
Protease bindingdefinition[GO:0002020]  
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  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Defense response to bacteriumdefinition[GO:0042742] silver  
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  • Ortholog Compara
Proteolysisdefinition[GO:0006508] silver  
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  • Ortholog Compara
Skeletal system developmentdefinition[GO:0001501]  
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  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.4.24.82: Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.  
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  • UniProtKB
EC 3.4.24.82: Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.  
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  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Degradation of the extracellular matrix  REACT_118572  
O-glycosylation of TSR domain-containing proteins  REACT_200626  
 
More information is available from:
Caution 
Has sometimes been referred to as ADAMTS2.  
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  • UniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS4
GenomeRNAi: 9507
PRO: PR:O75173