LRP5 - Low-density lipoprotein receptor-related protein 5 - human protein (Function)
 
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Protein
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LRP5 »  Low-density lipoprotein receptor-related protein 5
 
Gene name:  LRP5
Family name: LDLR
Entry whose protein(s) existence is based on evidence at protein level
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1 156 1
GENE REF ISO

Function

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Overview 
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.  
5
  • CuratedUniProtKB
GO molecular function 
Coreceptor activitydefinition[GO:0015026] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIBHF-UCL
Not  Toxin transporter activitydefinition[GO:0019534]  
1
  • IMPBHF-UCL
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147] silver  
  • IBARefGenome
GO biological process 
Adipose tissue developmentdefinition[GO:0060612]  
1
  • IMPBHF-UCL
Anatomical structure regressiondefinition[GO:0060033] silver  
  • IEAOrtholog Compara
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IBARefGenome
Apoptotic process involved in patterning of blood vesselsdefinition[GO:1902262] silver  
  • IEAOrtholog Compara
Bone marrow developmentdefinition[GO:0048539]  
1
  • IMPBHF-UCL
Bone morphogenesisdefinition[GO:0060349]  
3
  • IMPBHF-UCL
Bone remodelingdefinition[GO:0046849] silver  
  • IBARefGenome
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
4
  • IMPBHF-UCL
Cell migration involved in gastrulationdefinition[GO:0042074] silver  
  • IEAOrtholog Compara
Cell-cell signaling involved in mammary gland developmentdefinition[GO:0060764] silver  
  • IEAOrtholog Compara
Cholesterol homeostasisdefinition[GO:0042632]  
2
  • IMPBHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Embryonic camera-type eye morphogenesisdefinition[GO:0048596] silver  
  • IBARefGenome
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IBARefGenome
Embryonic retina morphogenesis in camera-type eyedefinition[GO:0060059] silver  
  • IBARefGenome
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Extracellular matrix-cell signalingdefinition[GO:0035426] silver  
  • IEAOrtholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IBARefGenome
Glucose catabolic processdefinition[GO:0006007]  
1
  • IMPBHF-UCL
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
1
  • IMPBHF-UCL
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
1
  • IMPBHF-UCL
Osteoblast developmentdefinition[GO:0002076] silver  
  • IBARefGenome
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • IMPBHF-UCL
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
1
  • IMPBHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IDABHF-UCL
Positive regulation of osteoblast proliferationdefinition[GO:0033690] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDABHF-UCL
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
1
  • IMPBHF-UCL
Regulation of bone remodelingdefinition[GO:0046850] silver  
  • IEAOrtholog Compara
Regulation of canonical Wnt signaling pathwaydefinition[GO:0060828]  
1
  • IMPBHF-UCL
Regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061178] silver  
  • IBARefGenome
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Retina morphogenesis in camera-type eyedefinition[GO:0060042]  
1
  • IMPBHF-UCL
Retinal blood vessel morphogenesisdefinition[GO:0061304]  
2
  • IMPBHF-UCL
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • IDABHF-UCL
Wnt signaling pathway involved in dorsal/ventral axis specificationdefinition[GO:0044332]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+4041  
According to Reactome, this protein belongs to the following pathways:
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
negative regulation of TCF-dependent signaling by WNT ligand antagonists  REACT_200643  
regulation of FZD by ubiquitination  REACT_200716  
TCF dependent signaling in response to WNT  REACT_200777  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRP5
GenomeRNAi: 4041
PRO: PR:O75197