GLRA3 - Glycine receptor subunit alpha-3 - human protein (Function)
 
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Protein
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References

 
GLRA3 »  Glycine receptor subunit alpha-3
 
Gene name:  GLRA3
Entry whose protein(s) existence is based on evidence at transcript level
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1 17 2
GENE REF ISO

Function

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Overview 
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.3.1  
GO molecular function 
Extracellular-glycine-gated chloride channel activitydefinition[GO:0016934] silver  
  • IEAInterPro 2 GO
Glycine bindingdefinition[GO:0016594] silver  
  • IEAInterPro 2 GO
Transmitter-gated ion channel activitydefinition[GO:0022824] silver  
  • IEAInterPro 2 GO
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+8001  
According to Reactome, this protein belongs to the following pathway:
Ligand-gated ion channel transport  REACT_25387  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GLRA3
GenomeRNAi: 8001
PRO: PR:O75311
Chemistry
GuidetoPHARMACOLOGY: 425