USP12 - Ubiquitin carboxyl-terminal hydrolase 12 - human protein (Function)
 
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USP12 »  Ubiquitin carboxyl-terminal hydrolase 12   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 12.
Gene name:  USP12
Family name: Peptidase C19 » USP12/USP46
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
2
  • IDAUniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
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  • IDAUniProtKB
GO biological process 
Protein deubiquitinationdefinition[GO:0016579]  
1
  • IDAUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 219333
PRO: PR:O75317