SEMA7A - Semaphorin-7A - human protein (Function)
 
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Protein
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SEMA7A »  Semaphorin-7A
 
Protein also known as:  John-Milton-Hargen human blood group Ag; CD antigen CD108.
Gene name:  SEMA7A
Family name: Semaphorin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 2
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.  
3
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Receptor activitydefinition[GO:0004872] silver  
  • IEAInterPro 2 GO
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • IDAUniProtKB
Positive regulation of axon extensiondefinition[GO:0045773]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of macrophage cytokine productiondefinition[GO:0060907]  
  • ISSOrtholog Curator
Regulation of inflammatory responsedefinition[GO:0050727]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+8482  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Inflammatory response  definition   [KW-0395]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SEMA7A
GenomeRNAi: 8482
PRO: PR:O75326