FKBP6 - Inactive peptidyl-prolyl cis-trans isomerase FKBP6 - human protein (Function)
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FKBP6 »  Inactive peptidyl-prolyl cis-trans isomerase FKBP6  (Inactive PPIase FKBP6)
Protein also known as:  36 kDa FK506-binding protein (FKBP-36).
Gene name:  FKBP6
Family name: FKBP6
Entry whose protein(s) existence is based on evidence at protein level
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Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).  
  • CuratedUniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528] silver  
  • IBARefGenome
Hsp90 protein bindingdefinition[GO:0051879]  
  • ISSOrtholog Curator
Contradiction  Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
  • IBARefGenome
  • ISSOrtholog Curator
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Chaperone-mediated protein foldingdefinition[GO:0061077] silver  
  • IBARefGenome
DNA methylation involved in gamete generationdefinition[GO:0043046]  
  • ISSOrtholog Curator
Gene silencing by RNAdefinition[GO:0031047]  
  • ISSOrtholog Curator
Meiotic nuclear divisiondefinition[GO:0007126]  
  • ISSOrtholog Curator
piRNA metabolic processdefinition[GO:0034587]  
  • ISSOrtholog Curator
Protein foldingdefinition[GO:0006457]  
  • ISSOrtholog Curator
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413] silver  
  • IBARefGenome
  • ISSOrtholog Curator
According to Reactome, this protein belongs to the following pathway:
Meiotic synapsis  REACT_75792  
Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity.  
  • CuratedUniProtKB


Biological process 
Differentiation  definition   [KW-0221]
Meiosis  definition   [KW-0469]
RNA-mediated gene silencing  definition   [KW-0943]
Spermatogenesis  definition   [KW-0744]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 8468
PRO: PR:O75344