PITX3 - Pituitary homeobox 3 - human protein (Function)
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PITX3 »  Pituitary homeobox 3
Protein also known as:  Paired-like homeodomain transcription factor 3.
Gene name:  PITX3
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
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Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Dopaminergic neuron differentiationdefinition[GO:0071542]  
  • ISSOrtholog Curator
Lens development in camera-type eyedefinition[GO:0002088]  
  • ISSOrtholog Curator
Lens fiber cell differentiationdefinition[GO:0070306] silver  
  • IEAOrtholog Compara
Lens morphogenesis in camera-type eyedefinition[GO:0002089]  
  • ISSOrtholog Curator
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901]  
  • ISSOrtholog Curator
Neuron developmentdefinition[GO:0048666] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887]  
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW


Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PITX3
GenomeRNAi: 5309
PRO: PR:O75364