TECTA - Alpha-tectorin - human protein (Sequence)
 
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Protein
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TECTA »  Alpha-tectorin
 
Gene name:  TECTA
Entry whose protein(s) existence is based on evidence at protein level
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1 51 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   2155 aaMass: 239527 Da,  pI: 5.23
MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK LAIPVFFFGV PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW ADVHNGIRGE IYYRETMEPA ILKRATKDIR KYFKDMATFS ATWVFIVTWE EVTFYGGSST TPVNTFQAVL VSDGSYTFTL FNYYEINWTT GTASGGDPLT GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN VPGRWAFKVD GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR QCLQTSSLPF FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV KVNDLVTSLP VTLDLGTVKI YQSGISTAVE TDFGLLVTFD GQHYASISVP GSYINSTCGL CGNYNKNPLD DFLRPDGRPA MSVLDLGESW RVYHADWKCD SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV VDPTAFVHSC VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC GCDFDGHYYT MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED GYQGCFPKRE TVCLLSQNQV LHTFDGASYA FPSEFSYTLL KTCPERPEYL EIDINKKKPD AGPAWLRGLR ILVADQEVKI GGIGASEVKL NGQEVELPFF HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT YFNCTGGLCG FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE SELCDSVARY ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC ETLTLGPICV DSCSEGCQCD EGYALLGSQC VTRSECGCNF EGHQLATNET FWVDLDCQIF CYCSGTDNRV HCETIPCKDD EYCMEEGGLY YCQARTDASC IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK FVVTAKNEDR DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD DLEMPMGLLA SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL CSLIPNQNAA FSKCHSKVNP TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS TCQTQGITVT GWRNYTSCTV TCPPNSHYES CVSVCQPRCA AIRLKSDCSH YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF WNSDCTRRCR CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN EEQILINDRN TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY NGFNVIKISI SERLQNKVCG LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS WKTNGMQKRP LAPSCNELQF SQYAAMCDNV HIQKMQGDGY CLKLTDMKGF FQPCYGLLDP LPFYESCYLD GCYSHKKFQL CGSLAAYGEA CRSFGILSTE WIEKENCSGV VEDPCVGADC PNRTCELGNG RELCGCIEPP PYGNNSHDII DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCTGI EGEDFISFQI NNTKGNCGNI VQSNGTHIMY KNTLWIESAN NTGNIITRDR TINVEFSCAY ELDIKISLDS VVKPMLSVIN LTVPTQEGSF ITKMALYKNA SYKHPYRQGE VVLTTRDVLY VGVFVVGADA THLILTLNKC YATPTRDSND KLRYFIIEGG CQNLKDNTIG IEENAVSLTC RFHVTVFKFI GDYDEVHLHC AVSLCDSEKY SCKITCPHNS RIATDYTKEP KEQIISVGPI RRKRLDWCED NGGCEQICTS RVDGPLCSCV TGTLQEDGKS CRASNSSMEL QVWTLLLIMI QISLWHFVYK SGTTS

Sequence

 show evidences
Domain 
Zona pellucida domain may enable to form filaments.  
  • CuratedUniProtKB
PTM 
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
Signal  definition   [KW-0732]
PTM 
Disulfide bond  definition   [KW-1015]
GPI-anchor  definition   [KW-0336]
Glycoprotein  definition   [KW-0325]
Lipoprotein  definition   [KW-0449]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
InterPro: IPR000742 [ EG-like dom ]
InterPro: IPR006552 [ VWC out ]
InterPro: IPR001507 [ ZP dom ]
InterPro: IPR025615 [ TILa dom ]
InterPro: IPR001007 [ VWF C ]
InterPro: IPR014853 [ Unchr dom Cys-rich ]
InterPro: IPR017977 [ ZP dom CS ]
InterPro: IPR002919 [ TIL dom ]
InterPro: IPR003886 [ Nidogen extracell dom ]
InterPro: IPR001846 [ VWF type-D ]
Pfam: PF00100 [ Zona pellucida ]
Pfam: PF12714 [ TILa ]
Pfam: PF01826 [ TIL ]
Pfam: PF08742 [ C8 ]
Pfam: PF00094 [ VWD ]
Pfam: PF06119 [ NIDO ]
PROSITE: PS51034 [ ZP 2 ]
PROSITE: PS51220 [ NIDO ]
PROSITE: PS51233 [ VWFD ]
PROSITE: PS00682 [ ZP 1 ]
SMART: SM00181 [ EGF ]
SMART: SM00216 [ VWD ]
SMART: SM00214 [ VWC ]
SMART: SM00832 [ C8 ]
SMART: SM00215 [ VWC out ]
SMART: SM00539 [ NIDO ]
SMART: SM00241 [ ZP ]
SUPFAM: SSF57567 [ SSF57567 ]
Genome annotation databases
Ensembl: Transcript: ENST00000264037;  Protein: ENSP00000264037;  Gene: ENSG00000109927.
Ensembl: Transcript: ENST00000392793;  Protein: ENSP00000376543;  Gene: ENSG00000109927.
KEGG: hsa:7007
UCSC: uc010rzo.2
Organism-specific databases
MGI: MGI:109575 [ Tecta ]
PTM databases
PhosphoSite: O75443
Phylogenomic databases
eggNOG: NOG317991
HOGENOM: HOG000168220
HOVERGEN: HBG079244
InParanoid: O75443
OMA: YLTFDGY
OrthoDB: EOG7SJD3N
PhylomeDB: O75443
Sequence databases
CCDS: CCDS8434.1 [ O75443-1 ]
EMBL: Genomic DNA:  AF055114 , AF055115 , AF055116 , AF055117 , AF055118 , AF055119 , AF055120 , AF055121 , AF055122 , AF055123 , AF055124 , AF055125 , AF055126 , AF055127 , AF055128 , AF055129 , AF055130 , AF055131 , AF055132 , AF055133 , AF055134 , AF055135 , AF055136 . Translation:  AAC26019.1 .
EMBL: Genomic DNA:  AP000826 . No translation available.
EMBL: Genomic DNA:  AP000646 . No translation available.
IPI: IPI00023051
RefSeq: Protein:  NP_005413.2. Nucleotide sequence:  NM_005422.2.
UniProtKB: O75443
Protocols and materials databases
DNASU: 7007