MAF - Transcription factor Maf - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MAF »  Transcription factor Maf
 
Protein also known as:  V-maf musculoaponeurotic fibrosarcoma oncogene homolog.
Gene name:  MAF
Family name: bZIP » Maf
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 2
GENE REF ISO

Function

 show evidences
Overview 
Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.  
5
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Cell developmentdefinition[GO:0048468] silver  
  • IEAOrtholog Compara
Cytokine productiondefinition[GO:0001816] silver  
  • IEAOrtholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Lens fiber cell differentiationdefinition[GO:0070306] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of chondrocyte differentiationdefinition[GO:0032330] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAF_(gene)
GenomeRNAi: 4094
PRO: PR:O75444