ERN1 - Serine/threonine-protein kinase/endoribonuclease IRE1 - human protein (Function)
 
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ERN1 »  Serine/threonine-protein kinase/endoribonuclease IRE1
 
Protein also known as:  Endoplasmic reticulum-to-nucleus signaling 1.
Gene name:  ERN1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 2
GENE REF ISO

Function

 show evidences
Overview 
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.  
5
  • UniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531]  
1
  • ParkinsonsUK-UCL
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Endoribonuclease activitydefinition[GO:0004521]  
4
  • ParkinsonsUK-UCL
  • WormBase
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Hsp70 protein bindingdefinition[GO:0030544]  
1
  • ParkinsonsUK-UCL
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • ParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • UniProtKB
  • ParkinsonsUK-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • ParkinsonsUK-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
GO biological process 
Activation of signaling protein activity involved in unfolded protein responsedefinition[GO:0006987]  
1
  • UniProtKB
Cell cycle arrestdefinition[GO:0007050]  
1
  • Ortholog Curator
Cellular response to glucose stimulusdefinition[GO:0071333]  
1
  • ParkinsonsUK-UCL
Cellular response to vascular endothelial growth factor stimulusdefinition[GO:0035924]  
1
  • UniProtKB
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • UniProtKB
HAC1-type intron splice site recognition and cleavagedefinition[GO:0070055]  
2
  • WormBase
  • ParkinsonsUK-UCL
Insulin metabolic processdefinition[GO:1901142]  
1
  • ParkinsonsUK-UCL
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
1
  • Ortholog Compara
IRE1-mediated unfolded protein responsedefinition[GO:0036498]  
1
  • ParkinsonsUK-UCL
mRNA catabolic processdefinition[GO:0006402]  
1
  • ParkinsonsUK-UCL
mRNA cleavagedefinition[GO:0006379]  
1
  • ParkinsonsUK-UCL
mRNA splicing, via endonucleolytic cleavage and ligationdefinition[GO:0070054]  
3
  • ParkinsonsUK-UCL
  • UniProtKB
Peptidyl-serine autophosphorylationdefinition[GO:0036289]  
1
  • ParkinsonsUK-UCL
Peptidyl-serine trans-autophosphorylationdefinition[GO:1990579]  
1
  • ParkinsonsUK-UCL
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • UniProtKB
Positive regulation of RNA splicingdefinition[GO:0033120]  
2
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
2
  • ParkinsonsUK-UCL
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of macroautophagydefinition[GO:0016241]  
1
  • ParkinsonsUK-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
RNA phosphodiester bond hydrolysis, endonucleolyticdefinition[GO:0090502] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsedefinition[GO:0030969]  
3
  • ParkinsonsUK-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.  
3
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2081  
Protein processing in endoplasmic reticulum  hsa04141+2081  
According to Reactome, this protein belongs to the following pathway:
IRE1alpha activates chaperones  REACT_18368  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Hydrolase  definition   [KW-0378]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ERN1
GenomeRNAi: 2081
PRO: PR:O75460
Chemistry
GuidetoPHARMACOLOGY: 2020