ERN1 - Serine/threonine-protein kinase/endoribonuclease IRE1 - human protein (Function)
 
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ERN1 »  Serine/threonine-protein kinase/endoribonuclease IRE1
 
Protein also known as:  Endoplasmic reticulum-to-nucleus signaling 1.
Gene name:  ERN1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 2
GENE REF ISO

Function

 show evidences
Overview 
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Endoribonuclease activitydefinition[GO:0004521]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Activation of signaling protein activity involved in unfolded protein responsedefinition[GO:0006987]  
1
  • IDAUniProtKB
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell cycle arrestdefinition[GO:0007050]  
  • ISSOrtholog Curator
mRNA processingdefinition[GO:0006397] silver  
  • IEAInterPro 2 GO
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2081  
Protein processing in endoplasmic reticulum  hsa04141+2081  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Hydrolase  definition   [KW-0378]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ERN1
GenomeRNAi: 2081
PRO: PR:O75460
Chemistry
GuidetoPHARMACOLOGY: 2020