LGR5 - Leucine-rich repeat-containing G-protein coupled receptor 5 - human protein (Function)
 
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LGR5 »  Leucine-rich repeat-containing G-protein coupled receptor 5
 
Protein also known as:  G-protein coupled receptor HG38.
Gene name:  LGR5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.  
5
  • CuratedUniProtKB
GO molecular function 
Not  G-protein coupled receptor activitydefinition[GO:0004930]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
2
  • IDAUniProtKB
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
2
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_200716  
Note 
LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium (PubMed19030762).  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LGR5
GenomeRNAi: 8549
PRO: PR:O75473
Chemistry
GuidetoPHARMACOLOGY: 148