SRSF10 - Serine/arginine-rich splicing factor 10 - human protein (Function)
 
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Protein
Gene
References

 
SRSF10 »  Serine/arginine-rich splicing factor 10
 
Protein also known as:  FUS-interacting serine-arginine-rich protein 1.
Gene name:  SRSF10
Family name: Splicing factor SR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 6
GENE REF ISO

Function

 show evidences
Overview 
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.  
3
  • CuratedUniProtKB
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • NASUniProtKB
RS domain bindingdefinition[GO:0050733]  
1
  • NASUniProtKB
Unfolded protein bindingdefinition[GO:0051082]  
1
  • NASUniProtKB
GO biological process 
Cytoplasmic transportdefinition[GO:0016482]  
1
  • IDAUniProtKB
mRNA export from nucleusdefinition[GO:0006406]  
1
  • NASUniProtKB
mRNA splice site selectiondefinition[GO:0006376]  
1
  • IDAUniProtKB
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • IDAUniProtKB
Negative regulation of mRNA splicing, via spliceosomedefinition[GO:0048025]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
RNA splicing, via transesterification reactionsdefinition[GO:0000375]  
1
  • IDAUniProtKB
Spliceosomal tri-snRNP complex assemblydefinition[GO:0000244]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+10772  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FUSIP1
PRO: PR:O75494