ECI2 - Enoyl-CoA delta isomerase 2, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ECI2 »  Enoyl-CoA delta isomerase 2, mitochondrial   [ EC 5.3.3.8 ]
 
Protein also known as:  Hepatocellular carcinoma-associated antigen 88.
Gene name:  ECI2
Family name: In the C-terminal section Enoyl-CoA hydratase/isomerase
Entry whose protein(s) existence is based on evidence at protein level
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1 25 2
GENE REF ISO

Function

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Overview 
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Dodecenoyl-CoA delta-isomerase activitydefinition[GO:0004165]  
1
  • IDAUniProtKB
  • IEAEC 2 GO
Fatty-acyl-CoA bindingdefinition[GO:0000062] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Isoform  Iso 2   Fatty acid catabolic processdefinition[GO:0009062]  
1
  • IDAUniProtKB
Metabolic processdefinition[GO:0008152] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.3.8: (3Z)-dodec-3-enoyl-CoA (2E)-dodec-2-enoyl-CoA.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fatty acid metabolism  hsa00071+10455  
Peroxisome  hsa04146+10455  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PECI_(gene)
GenomeRNAi: 10455
PRO: PR:O75521