LEFTY1 - Left-right determination factor 1 - human protein (Function)
 
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Gene
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LEFTY1 »  Left-right determination factor 1
 
Protein also known as:  Left-right determination factor B.
Gene name:  LEFTY1
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 21 1
GENE REF ISO

Function

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Overview 
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • RefGenome
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
GO biological process 
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell growthdefinition[GO:0016049] silver  
1
  • InterPro 2 GO
Determination of left/right symmetrydefinition[GO:0007368]  
1
  • Ortholog Curator
Heart morphogenesisdefinition[GO:0003007]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • Ortholog Curator
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • RefGenome
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+10637  
According to Reactome, this protein belongs to the following pathways:
Regulation of signaling by NODAL  REACT_111059  
Signaling by NODAL  REACT_111057  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10637
PRO: PR:O75610