SNRNP200 - U5 small nuclear ribonucleoprotein 200 kDa helicase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SNRNP200 »  U5 small nuclear ribonucleoprotein 200 kDa helicase   [ EC 3.6.4.13 ]
 
Protein also known as:  Activating signal cointegrator 1 complex subunit 3-like 1.
Gene name:  SNRNP200
Family name: Helicase » SKI2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 69 2
GENE REF ISO

Function

 show evidences
Overview 
RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-dependent helicase activitydefinition[GO:0008026]  
1
  • IDAHGNC
ATP-dependent RNA helicase activitydefinition[GO:0004004]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
Cis assembly of pre-catalytic spliceosomedefinition[GO:0000354]  
1
  • ICHGNC
mRNA splicing, via spliceosomedefinition[GO:0000398]  
2
  • ICUniProtKB
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.13: ATP + H(2)O ADP + phosphate.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+23020  
According to Reactome, this protein belongs to the following pathways:
mRNA Splicing - Major Pathway  REACT_467  
mRNA Splicing - Minor Pathway  REACT_1753  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASCC3L1
GenomeRNAi: 23020
PRO: PR:O75643