PPM1B - Protein phosphatase 1B - human protein (Function)
 
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PPM1B »  Protein phosphatase 1B   [ EC 3.1.3.16 ]
 
Protein also known as:  Protein phosphatase 2C isoform beta (PP2C-beta).
Gene name:  PPM1B
Family name: PP2C
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 5
GENE REF ISO

Function

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Overview 
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.  
2
  • CuratedUniProtKB
GO molecular function 
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
1
  • IDAUniProtKB
GO biological process 
N-terminal protein myristoylationdefinition[GO:0006499]  
  • ISSOrtholog Curator
Negative regulation of defense response to virusdefinition[GO:0050687]  
1
  • IMPUniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • IMPUniProtKB
Negative regulation of interferon-beta productiondefinition[GO:0032688]  
1
  • IMPUniProtKB
Negative regulation of NF-kappaB import into nucleusdefinition[GO:0042347]  
1
  • IMPUniProtKB
Peptidyl-threonine dephosphorylationdefinition[GO:0035970]  
1
  • IDAUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
2
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.16: [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium or manganese ions per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+5495  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPM1B
GenomeRNAi: 5495
PRO: PR:O75688