B3GALNT1 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 - human protein (Function)
 
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B3GALNT1 »  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1   [ EC 2.4.1.79 ]  (Beta-1,3-GalNAc-T1)
 
Protein also known as:  UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase.
Gene name:  B3GALNT1
Family name: Glycosyltransferase 31
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transfers N-acetylgalactosamine onto globotriaosylceramide.  
1
  • CuratedUniProtKB
GO molecular function 
Galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activitydefinition[GO:0047273]  
  • IEAEC 2 GO
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activitydefinition[GO:0008499] silver  
  • IEAOrtholog Compara
GO biological process 
Oligosaccharide biosynthetic processdefinition[GO:0009312] silver  
  • IEAOrtholog Compara
Protein glycosylationdefinition[GO:0006486]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.79: UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
2
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 31  GT31  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - globo series  hsa00603+8706  
Metabolic pathways  hsa01100+8706  
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: B3GALNT1
GenomeRNAi: 8706
PRO: PR:O75752